Endocrine Abstracts

Objective: Change in somatostatinergic tone (SST) is one of the key features of acromegaly, but the effect of tumor size on SST is not clear.Design: The aim of this study was to determine how SST changes depending upon the size of GH-producing pituitary tumors.Method: GH levels of 29 patients with newly diagnosed acromegaly were measured using a 75 g oral glucose tolerance test (OGTT), an insulin tolerance test (ITT) and an octreot...

Objective: TRH induces GH secretion presumably by expression of TRH receptor dedifferentiated in pitutiary tumors, but it is not clear how the TRH elegantly stimulates GH secretion in tumoral states.Design: The aim of this study was to investigate how GH-producing pituitary adenomas respond to TRH with respect to GH secretion and how it differs according to octreotide responses and their sizes of tumor.Method: GH levels of 45 patie...

Objective - Sarcopenic phenotype is associated with the increased risk of insulin resistance and type 2 diabetes. We investigated the proportion of sarcopenia and sarcopenic obesity (SO) and their clinical characteristics in patients with newly diagnosed type 2 diabetes.Research design and methods - We conducted a cross-sectional analysis of 133 (75 men, 58 women) patients with newly diagnosed type 2 diabetes. All patients underwent a 75 g oral glucose t...

Introduction: Activating somatic mutation of the BRAF gene (V600E) has been identified as the most common genetic event in papillary thyroid carcinoma (PTC) with a variable frequency (32–87%) in various races by different methods.In this study, we report the genetic analysis of BRAF mutation in a Korean cohort of 211 PTC by peptide nucleic acid clamp real-time PCR.Methods: PNA clamp real-time PCR was applied for BRAF analysis ...

Backgroud: The association with daily calcium intake and sarcopenia has not been well established.Objective: The objective was to assess the associate of daily calcium intake and sarcopenia.Methods: We analysed the fourth Korea National Health and Nutrition Examination Survey (KNHANES) in old adult (over 50 years), conducted in 2009. A total of 1964 non-obese (body mass index (BMI) <25 kg/m2) old adults (871 men and ...

Myostatin is expressed predominantly in skeletal muscle and at significantly lower levels in adipose tissue. The loss of myostatin by gene disruption prevents an age-related increase in adipose tissue mass and partially attenuates the obese and diabetic phenotypes. Inhibition of myostatin signaling could be useful to prevent and/or treat obesity and diabetes. Male OLETF and LETO rats as non-diabetic controls were treated with or without ALA (100 mg/kg per day) and/or insulin (...

Aims: We investigated the interrelationship between HbA1c, fructosamine, glycoalbumin (GA), 1,5-anhydroglucitol (1,5-AG) with glycemic variability data from continuous glucose monitoring system (CGMS).Methods: Seventy diabetic patients (mean age of 54 years including seven type 1 diabetes mellitus subjects) were enrolled, and all wore a CGMS for 72 hours. For the parameters of glucose excursion, mean glucose, standard deviation (SD) of glucose, the area ...

Introduction: Widespread availability of internet makes it an attractive communication tool among patients and providers. However, the clinical benefit of telemedical support on diabetes care remains inconclusive. This study is to determine whether an internet based mentoring program can improve glycemic control in type 1 diabetes (T1DM) patients with inadequate glycemic control.Methods: Patients with T1DM on intensive insulin therapy and with HbA1c &#x2...

Introduction: The natural history of primary hypophysitis is incompletely understood and best treatment remains controversial.Methods: We performed a retrospective study of 19 patients (mean age of 47 years, fifteen women and four men) who were diagnosed with primary hypophysitis in Samsung Medical Center in Seoul, Korea, from January 2001 to October 2011.Results: Two patients had recent pregnancy and underlying autoimmunity. Most ...

Aims: Nonalcoholic fatty liver disease (NAFLD) is reported to contribute to the development of type 2 diabetes, but it is largely unknown whether such a relationship between NAFLD and incident diabetes relates to the severity of NAFLD or it is independent. We aimed to evaluate the association of the severity of NAFLD with development of type 2 diabetes in a retrospective cohort of Korean subjects.Methods: This study included 7,849 individuals without dia...